ORC1 / YML065W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

ORC1/YML065W is an essential gene; null mutants are inviable. Reduction of function mutants exhibit delayed G1/S phase transition, decreased cell cycle progression in the S phase, decreased vegetative growth, and increased competitive fitness. Some reduction of function mutants are inviable. Repressible alleles exhibit abnormal cell cycle progression in the G1 phase. Overexpression of ORC1 results in decreased vegetative growth and reduced chromosome/plasmid maintenance. Conditional mutants show arrested cell cycle progression in the M phase, delayed G1/S phase transition, increased colony sectoring, increased heat sensitivity, decreased viability, abnormal chromosome/plasmid maintenance, and increased killer toxin resistance.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources