Phenotype Help

SUB1 / YMR039C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; null mutant displays heat sensitivity, increased mutation frequency, sensitivity to oxidative stress, abnormal phosphorylation of RNA polymerase II, and reduced tRNA levels; in large-scale studies, null mutant shows reduced competitive fitness and slow utilization of galactose; diploid homozygous null mutant shows increased chronological lifespan and sporulation efficiency, and decreased resistance to oxidative stress, UV, desiccation, and heat shock; null mutant shows altered resistance to a variety of chemicals

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

49 entries for 26 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
apoptosis: increased
classical genetics null
Allele: sub1-Δ
S288C20 μM paclitaxelDetails: increased apoptosis in the taxol treated null mutant based on elevated nuclear fragmentation and increased appearance of late apoptotic cells
Veerabhadrappa B, et al. (2021) PMID:34156070
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: sub1-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
chronological lifespan: decreased
competitive growth

competitive survival of mixed stationary phase co-cultures

null
Allele: sub1-Δ
S288CGaray E, et al. (2014) PMID:24586198
chronological lifespan: increased
homozygous diploid, large-scale surveynull
Allele: sub1-Δ
S288CBurtner CR, et al. (2011) PMID:21447998
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: sub1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.957
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: sub1-Δ
S288CMedia: glycerol medium, YPG
Qian W, et al. (2012) PMID:23103169
competitive fitness: decreased
systematic mutation setnull
Allele: sub1-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
competitive fitness: decreased
systematic mutation setnull
Allele: sub1-Δ
S288CMedia: synthetic complete medium, SC
Qian W, et al. (2012) PMID:23103169
desiccation resistance: decreased
homozygous diploid, systematic mutation setnull
Allele: sub1-Δ
S288CTreatment: pooled mutants subject to three cycles of growth to post-diauxic phase followed by desiccation and regrowth
Details: 2-fold or greater decreased survival after the treatment
Ratnakumar S, et al. (2011) PMID:20963216
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: sub1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0118
Pir P, et al. (2012) PMID:22244311
Showing 1 to 10 of 49 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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