New & Noteworthy

Predicted 3D Structures of Yeast Complexes

January 20, 2022

In an exciting new paper, Humphreys et al. describe the use of deep-learning-based algorithms to predict structures of not only single proteins, but assemblies of proteins. The team used rapid RoseTTAFold combined with the more accurate AlphaFold to build structural models for 106 previously unidentified protein assemblies and 806 complexes that had not been structurally characterized. The complexes have up to five subunits and are involved in numerous critical roles in cell biology.

Examples of predicted complexes from Humphreys et al.

Go look for your own proteins of interest at the ModelArchive and search in the Home page. Also find the link on the resources section of the SGD Interaction and Protein pages.

Categories: Data updates, Announcements, Uncategorized

Tags: yeast protein assembly, Saccharomyces cerevisiae, protein complex